解桂秋

作者: 时间:2021-07-02 点击数:

姓名

解桂秋

职称

副教授


办公地点

我院204室

办公电话

13180890093

邮箱

jiegq@jlu.edu.cn

教育背景

2004-2008 吉林大学生命科学学院生物化学与分子生物学 博士研究生

2000-2002 吉林大学生命科学学院 微生物与生化药学 硕士研究生

1996-2000 吉林大学生命科学学院 微生物与生化药学 本科生

工作经历

2018-现在, 吉林大学, bat365官网登录入口, 副教授/硕士生导师

2006-2018, 吉林大学, bat365官网登录入口, 讲师

2004-2006, 吉林大学, bat365官网登录入口, 助教

主讲课程

基因工程学; 药物基因组学; 生物信息学

研究领域

酶的筛选、功能研究及分子进化;酶催化生物合成

科研成果

发表文章:

1. Xu Y, Xuan X, Gao R & Xie G* 2023, ‘Increased expression levels of thermophilic serine protease TTHA0724 through signal peptide screening in Bacillus subtilis and applications of the enzyme’, International Journal of Molecular Sciences, vol. 24, 15950.

2. Lyu J, Zhang J, Zhu J, Chen S, Han T, Zhang Y, Gao R, Xie G* & Guo Z* 2022, ‘Molecular dynamics simulation guided distal mutation of Thermotoga naphthophila β-Glucosidase for significantly enhanced synthesis of galactooligosaccharides and expanded product scope’, International Journal of Biological Macromolecules, vol. 210, pp. 21-32.

3. Xie G, Shao Z, Zong L, Li X, Cong D & Huo R* 2019, ‘Heterologous expression and characterization of a novel subtilisin-like protease from a thermophilic Thermus thermophilus HB8’, International Journal of Biological Macromolecules, vol. 138, pp. 528-35.

4. Yang J, Gao R, Zhou Y, Anankanbil S, Li J, Xie G* & Guo Z* 2018, ‘β-Glucosidase from Thermotoga naphthophila RKU-10 for exclusive synthesis of galactotrisaccharides: Kinetics and thermodynamics insight into reaction mechanism’, Food Chemistry, vol. 240, pp. 422-9.

5. Zhou Y, Xie G, Chang L, Wang Y & Gao R* 2017, ‘Identification of an archaeal maltooligosyltrehalose trehalohydrolase encoded by an interrupted gene’, Extremophiles, vol. 21, no. 3, pp. 537-49.

6. Kong F, Yang J, Zhen Z, Liang T, Zhu D, Gao R & Xie G* 2015, ‘Gene cloning and molecular characterization of a β-glucosidase from Thermotoga Naphthophila RUK-10: an effective tool for synthesis of galacto-oligosaccharide and alkyl galactopyranosides’, Chemical Research in Chinese Universities, vol. 31, no. 5, pp. 774-80.

7. Kong F, Wang Y, Cao S, Gao R* & Xie G* 2014, ‘Cloning, purification and characterization of a thermostable β-galactosidase from Thermotoga naphthophila RUK-10’, Process Biochemistry, vol. 49, no.5, pp. 775-82.

发明专利:

1.一种重组嗜热中性蛋白酶及其在降解蛋白质中的应用, 中国专利ZL 2022 1 0505122.0,授权公告日2023.10.24.

2.嗜热酶及一锅法高效合成UDP-葡萄糖和UDP-葡萄糖醛酸的方法, 中国专利ZL 2022 1 0140823.9, 授权公告日2023.11.21.

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